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  • Home
  • Research Overview
    • Tumor organoid screenings for biology ​and precision medicine
    • Protein aggregation in cancer ​initiation and progression >
      • ReACp53
  • People
    • PI Bio
    • Open Positions
  • Publications
  • Funding
  • Lab News
    • News: Spring & Summer 21
    • News: Winter 20/21
    • Older News
  • Contact

For a complete list of papers & citations: Google Scholar

#24. Organoids

Zixuan Zhao*,  Xinyi Chen*, Anna M. Dowbaj*, Aleksandra Sljukic*, Kaitlin Bratlie*, Luda Lin*, Eliza Li Shan Fong, Gowri Manohari Balachander, Zhaowei Chen, Alice Soragni^, Meritxell Huch^, Yi Arial Zeng^, Qun Wang^ & Hanry Yu^
*Co-first authors; ^Co-corresponding authors 
Paper: Nature Reviews Methods Primers, 2022
Paper Preview: PrimeView, 2022

#23. A rapid platform for 3D patient-derived cutaneous neurofibroma organoid establishment and screening

​Huyen Thi Lam Nguyen, Emily Kohl, Jessica Bade, Stefan E. Eng, Anela Tosevska, Ahmad Al Shihabi, Jenny J. Hong,
Sarah Dry, Paul C. Boutros, Andre Panossian, Sara Gosline and 
A. Soragni

Preprint: bioRxiv, 2022

#22. Personalized chordoma organoids
for drug discovery studies

Ahmad Al Shihabi*, Ardalan Davarifar*, Huyen Thi Lam Nguyen, Nasrin Tavanaie, Scott D. Nelson,
​Jane Yanagawa, Noah Federman, Nicholas Bernthal, Francis Hornicek and 
A. Soragni

Preprint: bioRxiv, 2021
Paper: Science Advances, 2022
Additional Links:
  • UCLA Health Press Release
  • Technology Networks

#21. Drug screening at single organoid resolution
via bioprinting and interferometry

Peyton J Tebon*, Bowen Wang*, Alexander L Markowitz, Graeme Murray, Huyen Thi Lam Nguyen, Nasrin Tavanaie, 
Thang L Nguyen, Paul C Boutros,  Michael A Teitell^ and A. Soragni^

Preprint: bioRxiv, 2021
Additional Links:
  • Technology Networks​

#20. Cervical organoids go viral

Sara Sartini and A. Soragni
Preview: Cell Stem Cell, 2021

#19. p53 reactivation: Chasing the “untargetable” to circumvent resistance

A. Soragni
Book Chapter: Overcoming Ovarian Cancer Chemoresistance, Academic Press, 2020

#18. Patient-Derived Tumor Organoid Rings
for Histologic Characterization
and High-Throughput Screening

Huyen Thi Lam Nguyen and A. Soragni
Paper: STAR Protocols, 2020

#17. Of Scientists and Tweets

A. Soragni and A. Maitra
Paper: Nature Reviews Cancer, 2019

#16. A simple high-throughput approach identifies
​actionable drug responses in
​patient-derived tumor organoids

N. Phan, J. Hong, B. Tofig, M. Mapua, D. Elashoff, N.A. Motamed, J. Huang,  S. Memarzadeh,
​R. Damoiseaux,
A. Soragni. 
Paper: Communications Biology, 2019
Preprint: bioRxiv, 2017
Additional Links:
  • UCLA Press Release
  • ​ScienceNews
  • BioIT World
  • Cancer Therapy Advisor
  • The Scientist
  • Healthline

#15. Journal clubs in the time of preprints

 P. Avasthi, A. Soragni, J.N. Bembenek
 eLife 2018;7:e38532

#14. A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas

A. Soragni, D.M. Janzen, L.M. Johnson, A.G. Lindgren, A.T.-Q. Nguyen, E. Tiourin, A.B. Soriaga, J. Lu, L. Jiang, K.F. Faull, M. Pellegrini, S. Memarzadeh* and D.S. Eisenberg*. Cancer Cell, 2016, 29(1): 90-103
Additional Links:
  • UCLA Press Release
  • ​NIH NCI Cancer Currents Blog
  • Cancer Discovery Research Watch​ **
  • Nature Reviews Drug Discovery Highlight​ **
​
  • Science Translational Medicine Editors' Choice **
  • Cell Chemical Biology Select **
  • Cancer Research Breaking Advances **
      **Subscription Required

#13. Toxicity of Eosinophil MBP Is Repressed by Intracellular Crystallization and Promoted by Extracellular Aggregation

A. Soragni, S. Yousefi, C. Stoeckle, A.B. Soriaga, M.R. Sawaya, E. Kozlowski, I. Schmid, S. Radonjic-Hoesli, S. Boutet, G.J. Williams, M. Messerschmidt, M.M. Seibert, D. Cascio, N.A. Zatsepin, M. Burghammer, C. Riekel, J.-P. Colletier, R. Riek, D. Eisenberg and H.-U. Simon. Molecular Cell, 2015, 57(6):1011-21
Additional Links:
  • Press release Uni Bern
  • News UCLA-DOE 

#12. Superresolution Imaging of Amyloid Fibrils
​with Binding-Activated Probes

J. Ries, V. Udayar, A. Soragni, S. Hornemann, K.P.R. Nilsson, R. Riek, C. Hock, H. Ewers, A.A. Aguzzi and L. Rajendran.  ACS Chem Neurosci, 2013, 4(7):1057-17

#11. On-Surface Aggregation of α-Synuclein at Nanomolar Concentrations Results in Two Distinct Growth Mechanisms

M. Rabe, A. Soragni, N. Reynolds, D. Verdes, E. Liverani, S.Riek and S. Seeger. ACS Chem Neurosci, 2013, 4(3):408-17

#10. Mechanism of Membrane Interaction
​and Disruption by α-Synuclein

N.P. Reynolds**, A. Soragni**, M. Rabe, D. Verdes, E. Liverani, R. Riek and S. Seeger. ​JACS, 2011, 133(48):19366-75
**Co-first authors 

#9. The Amyloid-Congo Red Interface at Atomic Resolution

A. Schuetz, A. Soragni, S. Hornemann, A. Aguzzi, M. Ernst, A. Böckmann and B.H. Meier. Angewandte Chemie, 2011,  50(26):5956-60 
Additional Links:
  • Recommended by F1000

#8. In vivo demonstration that α-synuclein oligomers are toxic

B. Winner, R. Jappelli, S.K. Maji, L. Boyer, S. Aigner, C. Hetzer, T. Loher, M. Vilar, S. Campioni, C. Tzitzilonis, A. Soragni, S. Jessberger, H. Mira, A. Consiglio, E.H. Pham, P. Desplants, E. Masliah, F.H. Gage and R. Riek. PNAS, 2011, 108(10):4194-9
Additional Links:
  • Recommended by F1000

#7. Structural similarity between the prion domain of het-s and a homologue can explain amyloid cross-seeding in spite of limited sequence identity

C. Wasmer, A. Zimmer, R. Sabaté, A. Soragni, S.J. Saupe, C. Ritter and B.H. Meier. J Mol Biol, 2010,  402(2):311-25

#6. The mechanism of prion inhibition by HET-S​

J. Greenwald, C. Buhtz, C. Ritter, W. Kwiatkowski, S. Choe, M.L. Maddelein, F. Ness, S. Cescau, A. Soragni, D. Leitz, S.J. Saupe, and R. Riek. Molecular Cell, 2010, 38(6):889-99

#5. A Combined Solid-State NMR and MD Characterization of the Stability and Dynamics of the HET-s(218-289)
​Prion in its Amyloid Conformation​

A. Lange, Z. Gattin, H. van Melckebeke, C. Wasmer, A. Soragni, W. van Gunsteren and B. Meier. ChemBioChem, 2009, 10(10):1657-65

#4. Structural Characterization of Binding of
​Cu(II) to Tau Protein

A. Soragni, B. Zambelli, M.D. Mukrasch, J. Biernat, S. Jeganathan, C. Griesinger, S. Ciurli, E. Mandelkow and M. Zweckstetter. Biochemistry, 2008, 47(41):10841-51

#3. Infectious and noninfectious amyloids of the HET‐s (218–289) prion have different NMR spectra

C. Wasmer, A. Soragni, R. Sabaté, A. Lange, R. Riek and B.H. Meier. Angewandte Chemie, 2008, 47(31);5839-41
Additional Links:
  • Press release Angew Chemie
  • ETH Life News

#2. Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins

F.L. Aachmann, D.E. Fomenko, A. Soragni, V.N. Gladyshev, A. Dikiy. Journal of Biological Chemistry, 2007, 282(51):37063-44

#1. In Vitro Analysis of Protein-Operator Interactions of the NikR and Fur Metal-Responsive Regulators
​of Coregulated Genes in Helocobacter pylori

I. Delany, R. Ieva, A. Soragni, M. Hilleringman, R. Rappuoli and V. Scarlato. Journal of Bacteriology, 2005, 187(22):7703-15